Chiang Kai Shek College is the first institution of higher learning in the Philippines, founded by overseas Chinese-Filipinos. It offers education at all levels from preschool to graduate school.

In June 1939, Chiang Kai Shek High School was founded by prominent and hardworking Chinese in Manila, like Mr. Wong Chun Seng and Mr. Yu Khe Thai. It was named after Generalissimo Chiang Kai Shek to inspire young Filipino-Chinese to emulate the great personality and spirit of the late President. It initially offered a six-year program in Chinese and a four-year program in English. Three years later, the school bore the brunt of World War II– it was heavily damaged, and fourteen teachers and students were killed for participating in underground activities. The school reopened in December 1945. Under Principal Wong, together with the support of the Chinese community, it moved to its new site in August 1948.

In 1958, the Wong Chun Seng Memorial Preschool was established.

In November 2000, the Preschool and Kindergarten Department started offering the Montessori Class, and in June 2009, it opened the Day Care Center to provide respite for working parents.

With the implementation of the K to 12 Curriculum by the Department of Education under President Benigno Aquino in the year 2012, the Board of Trustees appointed Dr. Dory Poa as Consultant of the Board for Curriculum Development and Chairman of the Special Task Force on K+12. Five-year-old children in the Philippines are mandated to study Kindergarten. In June 2013, Dr. Bee Ching Ong Kian Koc retired, and Dr. Dory Poa was appointed as the new College President.